Purple Yam Polyphenol Extracts Exert Anticolitis and Anticolitis-Associated Colorectal Cancer Effects through Inactivation of NF-κB/p65 and STAT3 Signaling Pathways (2025)

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Histopathological analyses revealed that VA preserved colonic epithelial integrity and reduced inflammatory cell infiltration and goblet cell depletion, which are crucial for maintaining intestinal barrier function. This finding aligns with studies suggesting phenolic compounds, including VA, enhance epithelial barrier function and mitigate inflammatory damage [29,30]. Moreover, our study shows that VA treatment upregulates TJ proteins such as occludin, ZO-1, and claudin-5, further supporting its role in strengthening the intestinal barrier, as reported in similar studies involving other polyphenols [31,32].…”

confidence: 92%

et al. 2025

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…40,41 NF-κB is a key transcription factor involved in inflammation, cell growth and survival and plays a crucial role in the development and treatment of IBD. 42 A study found that oral administration of a Lactococcus lactis strain secreting a chimera of LfcinB and Lfampin downregulated the NF-κB pathway, alleviating the development of acute colitis in mice. 43 However, it is not known how LfcinB alone regulates inflammatory pathways.…”

confidence: 99%

et al. 2024

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…By influencing the gut microecological system and inflammatory pathways, Dioscorea opposite exhibits anti-tumor properties. Curcumin, derived from Curcuma longa , drives tumor cell apoptosis through mechanisms involving NF-κB, STAT3, and PI3K/Akt signaling [ 19 , 20 , 21 ]. The bioactive components in Glycyrrhiza uralensis , such as glycyrrhizin and licochalcone A, demonstrate promising anti-tumor potential through anti-inflammatory and anti-angiogenic mechanisms [ 22 , 23 ].…”

confidence: 99%

et al. 2025

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD).Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD.The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC).Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.